Regenerative aesthetics has transformed the way we approach facial rejuvenation. Instead of relying solely on synthetic fillers or aggressive resurfacing, many patients now prefer biological, autologous treatments that stimulate natural repair.

Two of the most popular regenerative options in 2025 are Endoret® PRGF (Plasma Rich in Growth Factors) and Plasma Gel, both available through EvoSkin providers.

Although these treatments originate from the patient’s own blood, they offer different clinical benefits, different textures, and different anti-aging outcomes. This guide breaks down how each treatment works—and helps you decide which is best for your needs or your patients.

What Is Endoret® PRGF?

Endoret® PRGF is a highly refined plasma-derived product developed through a patented protocol that isolates pure, activated growth factors without leukocytes or inflammatory cells.

How It Works

The plasma is processed to concentrate a high level of bioactive growth factors, which are then reinjected into the skin.

These growth factors:

• Stimulate fibroblasts
• Boost collagen and elastin production
• Improve microcirculation
• Accelerate tissue repair
• Reduce inflammation

Best Uses of PRGF

• Fine lines
• Early volume loss
• Under-eye rejuvenation
• Overall skin quality improvement
• Acne scars
• Combination therapy with energy-based treatments (lasers, EndoOne)

Why Patients Love It

PRGF provides a natural, subtle, and progressive improvement in skin texture, radiance, and elasticity.

What Is Plasma Gel?

Plasma Gel is created by heating the patient’s own plasma to convert its proteins into a smooth, filler-like gel.

The result is an autologous volumizer with a consistency similar to a light hyaluronic acid.

How It Works

• Plasma is heated to cause protein denaturation
• It thickens into a gel
• The gel is injected to restore volume and support soft tissue

Best Uses of Plasma Gel

• Filling superficial wrinkles
• Softening nasolabial folds
• Adding volume to tear troughs
• Refining jawline or cheek contours
• Structure support in combination with PRGF

Why Patients Love It

It behaves like a filler but is 100% natural, biocompatible, and resorbable, often with fewer complications.

Endoret® PRGF vs. Plasma Gel: Key Differences

Both treatments are safe, autologous, and free from synthetic substances. Instead of competing, they complement each other exceptionally well.

Which One Gives Better Anti-Aging Results?

It depends on your goals:

Choose Endoret® PRGF if you want:

• Better skin texture
• Brighter, healthier-looking skin
• Reduced fine lines
• Improved elasticity
• Faster healing from procedures
• Natural under-eye rejuvenation

PRGF is ideal for patients looking for biological improvement rather than structural change.

Choose Plasma Gel if you want:

• Immediate soft volume
• Smoother folds and hollows
• Tear trough refinement
• More definition in cheeks or jawline
• A natural alternative to fillers

Plasma Gel is best for shape, contour, and visible lifting.

Best Results Come From Combining Both

For many patients, the most powerful treatment is a combination of Endoret® PRGF + Plasma Gel in a layered protocol:

Step 1: Plasma Gel for Structure

Adds volume, supports tissues, lifts depressions.

Step 2: PRGF for Skin Quality

Improves texture, boosts collagen, reduces inflammation.

This dual approach addresses both shape and skin biology, delivering a comprehensive anti-aging result.

Safety and Downtime

Both therapies are:

• Autologous
• Minimally invasive
• Low risk
• Well tolerated
• Suitable for multiple skin types

Downtime is minimal, typically limited to mild swelling or small injection marks.

Which Treatment Should You Choose?

Here’s a simple guideline:

• If you want better texture, brightness, and biological rejuvenation → choose Endoret® PRGF
• If you want visible filling, contour, and immediate correction → choose Plasma Gel
• If you want the best of both worlds → combine them

Providers often customize protocols based on age, skin quality, volume loss, and aesthetic goals.

Conclusion: EvoSkin’s Regenerative Therapies Set a New Standard in 2025

Whether you choose PRGF, Plasma Gel, or a combined protocol, EvoSkin’s regenerative options offer:

• Natural results
• High safety profile
• Autologous treatment
• Long-term skin improvement

The future of anti-aging is regenerative—and EvoSkin is leading the way.