Introducing · Regenerative Protocol

ReversHA
Precision Regenerative
Skin Protocol

Advanced milk exosome-driven dermal restoration designed to improve texture, tone, hydration, and structural skin integrity.

✔ Texture Refinement ✔ Tone Improvement ✔ Barrier Repair ✔ Collagen Support
ReversHA treatment protocol

Unlike traditional approaches that rely on inflammation or volumization, ReversHA™ focuses on regenerative signaling pathways that support healthier skin architecture and long-term tissue quality improvement.

The Philosophy Behind ReversHA™

Beyond inflammation-based stimulation

Modern aesthetic medicine is moving beyond inflammation-based stimulation. ReversHA™ is built on regenerative signaling rather than swelling or forced tissue response.

Instead of triggering unnecessary inflammation, ReversHA™ provides biologic instructions that help support:

  • Fibroblast activation
  • Type I & III collagen reorganization
  • Barrier repair & hydration retention
  • Oxidative stress modulation
  • Tone and texture refinement

Clinical Perspective

This is not a filler.
This is skin architecture restoration.

Regenerative dermal remodeling
What Makes ReversHA™ Different?

Four regenerative technologies. One protocol.

01 Exosome-Guided Communication

Certified Milk-Derived Exosomes

ReversHA™ integrates certified milk-derived exosomes that function as biologic messengers and nanocarriers. These extracellular vesicles help support:

  • Tight junction protein expression
  • Filaggrin regulation
  • Lipid balance
  • Reduced TEWL
  • Improved cellular communication

Result

Stronger skin barrier and a healthier dermal microenvironment.

Milk exosome graphic
Exosome cellular communication
PDRN DNA fragments
02 Regenerative DNA Support (PDRN)

Salmon-Derived PDRN Fragments

Salmon-derived PDRN fragments help stimulate fibroblast activity and collagen pathway signaling.

Improved elasticity
Smoother texture
Progressive strengthening

Clinical Outcome

Supports visible improvement in overall skin quality without creating artificial volume.

03 Biomimetic Peptide Architecture

Targeted Peptide Technology

Targeted peptide technology supports:

  • Collagen I & III balance
  • Matrix remodeling
  • Dermal density enhancement

Why It Matters

This approach helps improve firmness and skin density while maintaining a natural appearance.

Peptide network
Glutathione antioxidant
04 Brightening & Oxidative Modulation

Glutathione + Niacinamide Synergy

ReversHA™ incorporates glutathione-based antioxidant support together with niacinamide synergy.

Brightens overall appearance
Promotes more even skin tone
Helps reduce dullness
Supports oxidative stress management

Result

Healthier, more radiant-looking skin.

Clinical Indications

ReversHA™ is ideal for

Early-to-moderate photoaging
Enlarged pores
Fine lines
Rough skin texture
Dull or fatigued skin
Post-inflammatory discoloration tendency
Barrier-compromised skin
Patients not ready for volumizing injectables
Microneedling clinical protocol
The Clinical Protocol

Microneedling-Assisted Diffusion

Controlled microchannels allow optimized delivery of regenerative ingredients.

0.3 mm

Needle Depth

4

Sessions

Every 2 Wks

Frequency

~2.5 mL

Per treatment zone

Why 0.3 mm?

This depth allows epidermal bypass while maintaining minimal trauma, making it ideal for bioactive ingredient diffusion without excessive inflammation.

Expected Clinical Outcomes

Following a complete 4-session protocol, patients may experience:

Improved skin luminosity
Smoother texture
Reduced pore visibility
Enhanced hydration
Progressive tightening effect
High patient satisfaction

Key Principle

ReversHA™ delivers progressive quality improvement rather than artificial volume enhancement.

The 12-Week Integrated Strategy

LongevHA™ + ReversHA™

ReversHA™ performs exceptionally well when preceded by biologic priming.

Weeks 1–5

LongevHA™

  • Cellular activation
  • Hydration priming
Weeks 6–12

ReversHA™

  • Intensive regenerative cycle
  • Dermal restoration
  • Skin quality enhancement
Integrated treatment strategy

Combined Benefits

Mitochondrial optimization
Improved dermal receptivity
Enhanced regenerative response
Advanced Combination Strategy

ReversHA™ can be combined with

RF Microneedling
Fractional Laser Resurfacing
HIFU Tightening
Energy-Based Collagen Devices

Clinical Advantage

In advanced device protocols, ReversHA™ acts as a biologic support layer while energy-based technologies focus on structural tissue contraction.

Safety & Candidate Screening

Responsible, screened application

Not Recommended For

  • Active skin infection
  • Autoimmune disease (relative contraindication)
  • History of keloids
  • Recent isotretinoin use
  • Known hypersensitivity to ingredients
  • Severe dairy sensitivity

Pre-Treatment Preparation

  • Stop retinoids 3–7 days before treatment
  • Avoid aggressive exfoliation
  • Follow provider-specific preparation guidelines
Who Is the Ideal Patient?

ReversHA™ is ideal for

Patients seeking natural skin improvement
Patients who decline fillers
Patients with early signs of aging
Combination therapy candidates
Post-laser recovery patients
Maintenance between injectable treatments
The EvoSkin Advantage

More than a product — a systemized strategy

When introducing ReversHA™ into your practice, EvoSkin provides:

Complete Clinical Protocol
Contraindication Checklist
Marketing Materials
Consent Templates
Combination Therapy Guidance
Sales Support

More Than a Product

ReversHA™ is a systemized regenerative strategy designed to support long-term practice success.

ReversHA treatment protocol
Frequently Asked Questions

Answers for practitioners

Is ReversHA™ a filler? +
No. ReversHA™ is not designed to volumize tissue. It is focused on improving skin quality and regenerative performance.
Is downtime significant? +
Most patients experience only mild erythema for approximately 24–48 hours.
How long do results last? +
Maintenance treatments every 3–4 months are generally recommended following the initial protocol.
Can ReversHA™ treat pigmentation? +
ReversHA™ supports tone regulation and skin quality improvement but is not intended as a melasma-specific drug treatment.
In Summary

ReversHA™ delivers

A next-generation regenerative skin protocol for practitioners focused on natural, biologically driven skin rejuvenation.

Barrier Restoration
Fibroblast Activation
Collagen Support
Texture Refinement
Tone Improvement
Regenerative Quality
ReversHA Final Summary

Bring ReversHA™ to your practice

Connect with our clinical team for protocols, training, and full practice support.